Hakim Ziyech has been ruled out after failing to recover from an Achilles injury, while Reece James on the bench after returning from a long-term hamstring problem at Wembley.
Cesar Azpilicueta is out with a muscle strain, while Trevoh Chalobah also misses out after an injury picked up against Liverpool.
Tuchel said in the build-up: “The situation was very, very good before the [Liverpool] match, because we had only Ben Chilwell out. Then the situation changed almost dramatically from this match.
“Now we have a lot of players with physical overload and we have some injuries from the match. It’s actually too much to comment on because it would be a long list, so we need to see.
“We had training today, the physios, the doctors are still working with the players to find out. And we can take the last decision tomorrow morning when we have the departure to Luton.
“[We will] see who’s ready to play, because we want to be ready but we suffered. It’s now the third time we’ve played extra-time, it was an intense match and this is where we are.”
Romelu Lukaku and Timo Werner both start, after coming off the bench against Liverpool, while Ruben Loftus-Cheek and Saul Niguez earn rare starts.
Chelsea XI: Kepa; Hudson-Odoi, Rudiger, Sarr; Kenedy; Loftus-Cheek, Jorginho, Saul, Alonso; Werner, Lukaku, Mount
Subs: Mendy, Hall, James, Williams, Kante, Kovacic, Barkley, Pulisic, Vale